Early Online

Volume 3 Issue 1 - 2018

  • Editorial

    Reflexions about Immunoradiometric Tsh and Trh Test During

    Sidibe EH*

    Editorial: Since the introduction of third generation of the TSH assay methods, TRH test remains only essential for limited domains. But for some authors, application of immunoradiometric assays combined with TRH test have not sufficiently evaluated as remarked by some authors. Thyreotroph cell has a potent desiodase and active in normal subject explaining the strong correlation between T4 and TSH. Interindividual variability of the activity of desiodase enzyme is very possible because of genetic polymorphism. We have studied prospectively and determined in and homogenous patients population with treated primary hypothyroidism, a real over dosage by an abolished first generation immune radiometric TSH to TRH and given optimal dosage of levothyroxine during substitutive thyroid hormonotherapy.
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  • Editorial

    Infantilo-Juvenile Diabetes in Dakar

    Sidibe EH*

    Editorial: In infants, the importance of management is justified by knowledge of factors and characteristics of infantilo-juvénile diabetes epidemiology. It is interesting to describe socio-demography of infantilo-juvénile diabetes and insulin dosages profiles. In Senegal, a retrospective study has concerned 79 cases. A comp arative study between subject less 18 years aged (44 cases) compaired to those of more than 19 years and treated by insulin and in all cases age less than 40 years (35 cases).
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  • Editorial

    Hypertension and Diabete Mellitus

    Sidibe EH*

    Editorial: Type 2 diabetes melllitus in a frequent condition with high mortality which management as so far may be both individualized and integrated and not only focused on glycemid control but concern also the other vascular risk factors frequently associated (mainly arterial hypertension). Sympathetic modulation role evocated in rat models of non insulin-dependent mellitus with arterial hypertension induced by sodium chloride shows the potential benefit of alpha and beta adrenoblockers. Arterial hypertension frequency and data about lead to interest in evaluation of treatment and brief literature review with Centre MarcSankaléDakarUniversityHospital setting of study.
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  • Editorial

    Philologic Reflexions about Immunoradiometric Tsh and Trh Test During Optimal Thyroid Hormonal Therapy Infantilo-Juvenile Diabetes and Hypertension Associated with Diabetes Mellitus in Dakar

    Sidibe EH*

    Editorial: In infants, the importance of management is justified by knowledge of factors and characteristics of infantilo-juvénile diabetes epidemiology. It is interesting to describe socio-demography of infantilo-juvénile diabetes and insulin dosages profiles. In Senegal, a retrospective study have concerned 79 casesSince the introduction of third generation of the TSH assay methods, TRH test remains only essential for limited domains. But for some authors, application of immunoradiometric assays combined with TRH test have not sufficiently evaluated as remarked by some authors. Thyreotroph cell has a potent desiodase and active in normal subject explaining the strong correlation between T4 and TSH. Interindividual variability of the activity of desiodase enzyme is very possible because of genetic polymorphism. We have studied prospectively and determined in and homogenous patients population with treated primary hypothyroidism, a real over dosage by an abolished first generation immunoradiometric TSH to TRH and given optimal dosage of levothyroxine during substitutive thyroid hormono-therapy.Type 2 diabetes mellitus in a frequent condition with high mortality which management as so far may be both individualized and integrated and not only focused on glycemic control but concern also the other vascular risk factors frequently associated (mainly arterial hypertension). Sympathetic modulation role evocated in rat models of non insulin-dependent mellitus with arterial hypertension induced by sodium chloride shows the potential benefit of alpha and beta adreno-blockers. Arterial hypertension frequency and data about lead to interest in evaluation of treatment and brief literature review with Centre Marc Sankalé Dakar University Hospital setting of study.
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  • Editorial

    Embryo Endocrine Thyroid Pancreas Review Development in Utero

    Sidibe EH*

    Editorial: Molecular targets of developmental exposure to bisphenol a in diabesity: a focus on endoderm-derived organs. Several studies associate foetal human exposure to bisphenol A (BPA) to metabolic/endocrine diseases, mainly diabesity. They describe the role of BPA in the disruption of pancreatic beta cell, adipocyte and hepatocyte functions. Indeed, the complexity of the diabesity phenotype is due to the involvement of different endoderm-derived organs, all targets of BPA. Here, we analyse this point delineating a picture of different mechanisms of BPA toxicity in endoderm-derived organs leading to diabesity. Moving from epidemiological data, we summarize the in vivo experimental data of the BPA effects on endoderm-derived organs (thyroid, pancreas, liver, gut, prostate and lung) after prenatal exposure. Mainly, we gather molecular data evidencing harmful effects at low-dose exposure, pointing to the risk to human health. Although the fragmentation of molecular data does not allow a clear conclusion to be drawn, the present work indicates that the developmental exposure to BPA represents a risk for endoderm-derived organs development as it deregulates the gene expression from the earliest developmental stages. A more systematic analysis of BPA impact on the transcriptomes of endoderm-derived organs is still missing. Here, we suggest in vitro toxicogenomics approaches as a tool for the identification of common mechanisms of BPA toxicity leading to the diabesity in organs having the same developmental origin [1]. Analysis of the cell-free amniotic fluid transcriptome expressed during the euploid mid-trimester of pregnancy.
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  • Case Report

    Deiodinase in Embryo Development

    Sidibe El H*

    Abstract: Neutrophils are essential effectors cells of the innate immune system that have recently been recognized as thyroid hormone (TH) target cells. Cellular TH bioavailability is regulated by the deiodinase enzymes, which can activate or inactivate TH. We have previously shown that the TH inactivating enzyme type 3 deiodinase (D3) is present in neutrophils. Furthermore, D3 knockout (D3KO) mice show impaired bacterial killing upon infection. We hypothesized that D3 plays a role in neutrophil function during infection by actively regulating local TH availability. We measured TH concentrations in cerebrospinal fluid (CSF) from patients with bacterial meningitis and controls. Bacterial meningitis resulted in marked changes in CSF TH levels, characterized by a strong increase of thyroxine and reverse-triiodothyronine concentrations. This altered TH profile was consistent with elevated D3 activity in infiltrating neutrophils at the site of infection. D3 knockdown in zebrafish embryos with pneumococcal meningitis resulted in increased mortality and reduced neutrophil infiltration during infection. Finally, stimulated neutrophils from female D3KO mice exhibited impaired NADPH-oxidase activity, an important component of the neutrophil bacterial killing machinery. These consistent findings across experimental models strongly support a critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential [1].
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  • Editorial

    Neurodegenerative Diseases Can be Related to Embryonic Iodine Deficiency

    Sidibe El H*

    Summary: The thyroid hormone is the master regulator of differentiation and growth through transporters, desiodase II and III. Observations reveal that cord TSH is more sensitive to the iodine status of the mother. Iodine requirements increase more than 50% during pregnancy.
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  • Editorial

    Cell Pouch Embryo Metabolism Regulation Stage

    Sidibe El H*

    Background: Piwi proteins are essential for germ line development, stem cell maintenance, and more recently found to function in epigenetic and somatic gene regulation. In the sea urchin Strongylocentrotus purpuratus, two Piwi proteins, Seawi and Piwi-like1, have been identified, yet their functional contributions have not been reported.
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  • Editorial

    Orphan Nuclear Deiodinase Receptors

    Sidibe El H*

    Objective: Selenium neutralizes interleukin-1β (IL-1β) induced inflammatory responses in chondrocytes. We investigated potential mechanisms for this through in vitro knock down of three major selenoproteins, Iodothyronine Deiodinase-2 (DIO2), Glutathione Peroxidase-1 (GPX1), and Thioredoxin Reductase-1 (TR1) in primary human chondrocytes.
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